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Chemopreventive effects of alpha-santalol on skin tumor development in CD-1 and SENCAR mice.

Abstract
Studies from our laboratory have indicated skin cancer chemopreventive effectsof sandalwood oil in CD-1 mice. The purpose of this investigation was to study the skin cancer chemopreventive effects of alpha-santalol, a principal component of sandalwood oil in CD-1 and SENCAR mice. alpha-Santalol was isolated from sandalwood oil by distillation under vacuum and characterized by nuclear magnetic resonance and gas chromatography-mass spectrometry. Chemopreventive effects of alpha-santalol were determined during initiation and promotion phase in female CD-1 and SENCAR mice. Carcinogenesis was initiated with 7,12-dimethylbenz(a)anthracene and promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA). The effects of alpha-santalol treatment on TPA-induced epidermal ornithine decarboxylase (ODC) activity and (3)H-thymidine incorporation in epidermal DNA of CD-1 and SENCAR mice were also investigated. alpha-Santalol treatment during promotion phase delayed the papilloma development by 2 weeks in both CD-1 and SENCAR strains of mice. alpha-Santalol treatment during promotion phase significantly (P < 0.05) decreased the papilloma incidence and multiplicity when compared with control and treatment during initiation phase during 20 weeks of promotion in both CD-1 and SENCAR strains of mice. alpha-Santalol treatment resulted in a significant (P < 0.05) inhibition in TPA-induced ODC activity and incorporation of (3)H-thymidine in DNA in the epidermis of both strains of mice. alpha-Santalol significantly prevents papilloma development during promotion phase of 7,12-dimethylbenz(a)anthracene-TPA carcinogenesis protocol in both CD-1 and SENCAR mice, possibly by inhibiting TPA-induced ODC activity and DNA synthesis. alpha-Santalol could be an effective chemopreventive agent for skin cancer. Additional experimental and clinical studies are needed to investigate the chemopreventive effect of alpha-santalol in skin cancer.
AuthorsChandradhar Dwivedi, Xiangming Guan, Wendy L Harmsen, Alison L Voss, Dawn E Goetz-Parten, Erin M Koopman, Kelly M Johnson, Hima B Valluri, Duane P Matthees
JournalCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 12 Issue 2 Pg. 151-6 (Feb 2003) ISSN: 1055-9965 [Print] United States
PMID12582025 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Carcinogens
  • Plant Oils
  • Sesquiterpenes
  • Ornithine Decarboxylase
  • Tetradecanoylphorbol Acetate
  • sandalwood oil
Topics
  • Administration, Topical
  • Animals
  • Carcinogens (adverse effects)
  • Chemoprevention
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Female
  • Incidence
  • Mice
  • Mice, Inbred SENCAR
  • Ornithine Decarboxylase (drug effects)
  • Papilloma (epidemiology, prevention & control)
  • Plant Oils (administration & dosage, therapeutic use)
  • Sesquiterpenes (administration & dosage, therapeutic use)
  • Skin Neoplasms (epidemiology, prevention & control)
  • Tetradecanoylphorbol Acetate (adverse effects)
  • Time Factors
  • Treatment Outcome
  • Women's Health

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