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[Establishment of transgenic mouse models carrying human polymeric immunoglobulin receptor gene].

AbstractOBJECTIVE:
To establish transgenic mouse models carrying human polymeric immunoglobulin receptor (pIgR) gene to render the mice prone to EBV infection in normal condition, thereby to facilitate the study of the role of Epstein-Barr virus (EBV) in the pathogenesis of nasopharyngeal carcinoma.
METHOD:
By means of microinjection, pIgR gene under the regulation by kerotinocyte-specific promoter ED-L2 was introduced into the pronuclei of mouse zygote, which was transferred into pseudo- pregnant female mice to induce nasopharynx-specific pIgR expression in the founder mice.
RESULT:
Six out of the 16 founder mice (37.5%) was tested by PCR to be pIgR-positive, while Southern blotting identified only 2 positive mice.
CONCLUSION:
Transgenic mice harboring pIgR gene can be used potentially as a new model for studying the pothogenesis of nasopharyngeal carcinoma by EBV.
AuthorsLi-chun Lü, Ying He, Ke Lan, Xin-ming Shen, Hua Huang, Pei-zhou Jiang, Shuang Wang, Shou-jun Xu, Kai-tai Yao
JournalDi 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA (Di Yi Jun Yi Da Xue Xue Bao) Vol. 23 Issue 2 Pg. 127-9 (Feb 2003) ISSN: 1000-2588 [Print] China
PMID12581959 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Polymeric Immunoglobulin
Topics
  • Animals
  • Epstein-Barr Virus Infections
  • Female
  • Herpesvirus 4, Human
  • Humans
  • Mice
  • Mice, Transgenic
  • Receptors, Polymeric Immunoglobulin (genetics, metabolism)

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