Calcifying odontogenic cyst: clinicopathological features and immunohistochemical profile of 10 cases.

Abstract

BACKGROUND:

Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion with few studies describing its immunohistochemical profile and proliferative activity reported in the literature.

METHODS:

Clinical and histological features and immunohistochemical expression of cytokeratins, Mel-CAM (CD146), bcl-2, PCNA and ki-67, in 10 cases of COC were studied.

RESULTS:

All 10 cases affected the maxilla, eight intraosseous and two peripheral. Five central cases were cystic and three were cystic associated with odontoma, and the two extraosseous showed solid histological pattern; immunohistochemistry was positive for cytokeratins 8, 14, 19, AE1/AE3 and 34betaE12 and bcl-2 in all cases, and Mel-CAM in six cases. Proliferative activity was greater in the epithelium of central cystic COC in relation to COC associated with odontoma and peripheral lesions.

CONCLUSION:

Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. There were no recurrences after surgery, irrespective of their proliferative activity.

• Authors: Eduardo Rodrigues Fregnani, Fábio Ramôa Pires, Rivera Daniel Quezada, Ie Ming Shih, Pablo Agustin Vargas, Oslei Paes de Almeida
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 32 Issue 3 Pg. 163-70 (Mar 2003) ISSN: 0904-2512 [Print] Denmark
• PMID: 12581386 (Publication Type: Journal Article)

Chemical References

• Antigens, CD
• Antigens, Differentiation, T-Lymphocyte
• Biomarkers, Tumor
• CD146 Antigen
• Ki-67 Antigen
• MCAM protein, human
• Membrane Glycoproteins
• Neural Cell Adhesion Molecules
• Proliferating Cell Nuclear Antigen
• Proto-Oncogene Proteins c-bcl-2
• Keratins

Topics

• Antigens, CD
• Antigens, Differentiation, T-Lymphocyte (analysis)
• Biomarkers, Tumor (analysis)
• CD146 Antigen
• Cell Division
• Humans
• Immunohistochemistry
• Keratins (analysis, classification)
• Ki-67 Antigen (analysis)
• Maxillary Neoplasms (pathology)
• Membrane Glycoproteins (analysis)
• Neoplasms, Multiple Primary (pathology)
• Neural Cell Adhesion Molecules
• Odontogenic Cyst, Calcifying (pathology)
• Odontoma (pathology)
• Proliferating Cell Nuclear Antigen (analysis)
• Proto-Oncogene Proteins c-bcl-2 (analysis)