Abstract |
Granular cell tumors (GCTs) typically express S-100 protein, which has been used as a marker in differential diagnosis. Calretinin, a calcium-binding protein related structurally to S-100, and inhibin, a polypeptide hormone secreted primarily by ovarian granulosa cells and testicular Sertoli cells and functioning as an inhibitor for pituitary follicle-stimulating hormone secretion, are potentially useful but not well-evaluated markers for GCTs. We studied 43 cases of GCT with antibodies to calretinin, the inhibin alpha-subunit, and S-100 protein. All tumors were positive for inhibin alpha-subunit and S-100 protein, with 50% or more cells showing moderate to strong staining. Forty tumors (93%) were positive for calretinin, ranging from focal weak to diffuse strong staining. Enhanced staining for calretinin in the tumor cells adjacent to hyperplastic squamous epithelium was observed in 9 of 13 cases showing pseudoepitheliomatous hyperplasia. Calretinin and the inhibin alpha-subunit are useful markers for GCTs. The expression of calretinin, a primarily neuronal protein, in GCTs further supports its neural differentiation or derivation. The elevated calretinin expression in the tumor cells adjacent to the hyperplastic squamous epithelium suggests a role for calretinin in the tumor cells-squamous epithelium interaction.
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Authors | Samson W Fine, Maomi Li |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 119
Issue 2
Pg. 259-64
(Feb 2003)
ISSN: 0002-9173 [Print] England |
PMID | 12579997
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CALB2 protein, human
- Calbindin 2
- S100 Calcium Binding Protein G
- S100 Proteins
- inhibin-alpha subunit
- Inhibins
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Topics |
- Biomarkers, Tumor
(metabolism)
- Calbindin 2
- Cell Count
- Female
- Granular Cell Tumor
(etiology, metabolism, pathology)
- Humans
- Immunohistochemistry
- Inhibins
(metabolism)
- Neoplasms, Glandular and Epithelial
- S100 Calcium Binding Protein G
(metabolism)
- S100 Proteins
(metabolism)
- Schwann Cells
(pathology)
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