Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors.

Granular cell tumors (GCTs) typically express S-100 protein, which has been used as a marker in differential diagnosis. Calretinin, a calcium-binding protein related structurally to S-100, and inhibin, a polypeptide hormone secreted primarily by ovarian granulosa cells and testicular Sertoli cells and functioning as an inhibitor for pituitary follicle-stimulating hormone secretion, are potentially useful but not well-evaluated markers for GCTs. We studied 43 cases of GCT with antibodies to calretinin, the inhibin alpha-subunit, and S-100 protein. All tumors were positive for inhibin alpha-subunit and S-100 protein, with 50% or more cells showing moderate to strong staining. Forty tumors (93%) were positive for calretinin, ranging from focal weak to diffuse strong staining. Enhanced staining for calretinin in the tumor cells adjacent to hyperplastic squamous epithelium was observed in 9 of 13 cases showing pseudoepitheliomatous hyperplasia. Calretinin and the inhibin alpha-subunit are useful markers for GCTs. The expression of calretinin, a primarily neuronal protein, in GCTs further supports its neural differentiation or derivation. The elevated calretinin expression in the tumor cells adjacent to the hyperplastic squamous epithelium suggests a role for calretinin in the tumor cells-squamous epithelium interaction.
AuthorsSamson W Fine, Maomi Li
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 119 Issue 2 Pg. 259-64 (Feb 2003) ISSN: 0002-9173 [Print] United States
PMID12579997 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • CALB2 protein, human
  • Calbindin 2
  • S100 Calcium Binding Protein G
  • S100 Proteins
  • inhibin-alpha subunit
  • Inhibins
  • Biomarkers, Tumor (metabolism)
  • Calbindin 2
  • Cell Count
  • Female
  • Granular Cell Tumor (etiology, metabolism, pathology)
  • Humans
  • Immunohistochemistry
  • Inhibins (metabolism)
  • Neoplasms, Glandular and Epithelial
  • S100 Calcium Binding Protein G (metabolism)
  • S100 Proteins (metabolism)
  • Schwann Cells (pathology)

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