Abstract | AIM: METHODS: The aqueous extract of Sangzhi was given orally to alloxan diabetic rats for 15 days. The hyperglycemic symptoms were observed. The blood glucose, lipid levels and the nephrotic representations were measured. RESULTS: When alloxan diabetic rats on high-calorie chow were treated with SZ, the hyperglycemic symptoms were improved, the blood lipid levels were improved, the ratio of kidney over body weight and the blood N-acetyl-beta-D-glucosaminidase (NAG) activity were lowered. The degree of renal pathological changes was significantly reduced. CONCLUSION: SZ may be useful for treating diabetes and its complications.
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Authors | Fei Ye, Zhu-fang Shen, Feng-xia Qiao, De-yu Zhao, Ming-zhi Xie |
Journal | Yao xue xue bao = Acta pharmaceutica Sinica
(Yao Xue Xue Bao)
Vol. 37
Issue 2
Pg. 108-12
(Feb 2002)
ISSN: 0513-4870 [Print] China |
PMID | 12579953
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Enzyme Inhibitors
- Glycoside Hydrolase Inhibitors
- Hypoglycemic Agents
- Triglycerides
- alpha-Glucosidases
- Acetylglucosaminidase
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Topics |
- Acetylglucosaminidase
(blood)
- Animals
- Blood Glucose
(metabolism)
- Diabetes Mellitus, Experimental
(complications, drug therapy, metabolism)
- Diabetic Nephropathies
(etiology, metabolism, prevention & control)
- Disease Models, Animal
- Enzyme Inhibitors
(therapeutic use)
- Glycoside Hydrolase Inhibitors
- Hypoglycemic Agents
(isolation & purification, pharmacology, therapeutic use)
- Kidney
(pathology)
- Male
- Morus
(chemistry)
- Plants, Medicinal
(chemistry)
- Rats
- Rats, Wistar
- Triglycerides
(blood)
- alpha-Glucosidases
(isolation & purification)
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