[Protective effect of ONO-1078, a leukotriene antagonist, on focal cerebral ischemia in mice].

Abstract

AIM:

To determine whether ONO-1078 [pranlukast, 4-oxo-8-[p-(4-phenylbutyloxy) benzoyl-amino]-2-(tetrazol-5-yl)-4H-1-benzopyran hemihydrate], a potent leukotriene antagonist, has protective effect on focal cerebral ischemia in mice.

METHODS:

Focal cerebral ischemia was induced by permanent middle cerebral artery (MCA) occlusion in mice. ONO-1078 (0.01, 0.05, 0.10 mg.kg-1), dexamethasone (0.5 mg.kg-1), nimodipine (0.2 mg.kg-1) or saline (control) were injected i.p. once daily for 3 days, and 30 min before MCA occlusion. Twenty-four hours after cerebral ischemia, the neurological scores were evaluated, infarct volumes and areas of the right and left cerebral hemispheres were measured by computer imaging analysis.

RESULTS:

ONO-1078, dexamethasone and nimodipine reduced the neurological scores. ONO-1078 and dexamethasone reduced the ratio of right/left hemisphere area, indicating inhibition of brain edema, while nimodipine showed no effect. ONO-1078 dose-dependently reduced infarct size, and dexamethasone and nimodipine showed the same effect.

CONCLUSION:

ONO-1078 showed protective effect on focal cerebral ischemia. This may represent a novel approach to the treatment of acute cerebral ischemia.

• Authors: L H Zeng, W P Zhang, R D Wang, P L Wang, E Q Wei
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 36 Issue 2 Pg. 148-50 (Feb 2001) ISSN: 0513-4870 [Print] China
• PMID: 12579886 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chromones
• Leukotriene Antagonists
• Neuroprotective Agents
• Nimodipine
• Dexamethasone
• pranlukast

Topics

• Animals
• Brain (pathology)
• Brain Ischemia (etiology, pathology)
• Chromones (pharmacology)
• Dexamethasone (pharmacology)
• Infarction, Middle Cerebral Artery (complications)
• Leukotriene Antagonists (pharmacology)
• Male
• Mice
• Neuroprotective Agents (pharmacology)
• Nimodipine (pharmacology)