[Inhibitory effect of boanmycin on the growth of colon carcinoma 26 and hepatic metastasis in mice].

Abstract

AIM:

To investigate the therapeutic effect of boanmycin (BAM, bleomycin A6) on colon carcinoma 26 and its hepatic metastasis in mice.

METHODS:

A series of models including subcutaneous transplantation, orthotopic transplantation in cecum subserosa, intra-hepatic transplantation of tumor, and intrasplenic transplantation of tumor accompanied with hepatic metastases were employed. In addition, LEICA Q 500IW image analysis system was used to determine the area of metastatic lesions in the liver in histopathological sections.

RESULTS:

BAM at 5 mg.kg-1 and 2.5 mg.kg-1 inhibited the growth of subcutaneous tumors by 78.7% and 61.9%, and the orthotopic tumors by 99.4% and 90.0%; and the intra-hepatic tumors by 86.9% and 75.7%, respectively. Determined by the numbers of metastatic nodules, BAM at 10 mg.kg-1 and 5 mg.kg-1 inhibited hepatic metastases from intra-splenic transplantation by 97.6% and 56.8%; and evaluated by image analysis of metastatic lesions, by 100% and 63.3%, respectively.

CONCLUSION:

Boanmycin is highly effective in a panel of models including the subcutaneous, orthotopic, intra-hepatic transplanted tumors, and hepatic metastases of murine colon carcinoma 26.

• Authors: X J Liu, Y Li, Y S Zhen
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 36 Issue 1 Pg. 14-8 (Jan 2001) ISSN: 0513-4870 [Print] China
• PMID: 12579853 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• bleomycin A6
• Bleomycin

Topics

• Animals
• Antibiotics, Antineoplastic (therapeutic use)
• Bleomycin (analogs & derivatives, therapeutic use)
• Colonic Neoplasms (drug therapy, pathology)
• Liver (pathology)
• Liver Neoplasms (drug therapy, secondary)
• Male
• Mice
• Mice, Inbred BALB C
• Neoplasm Transplantation