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[Experimental studies on the anti-thrombosis effect of 3,4-oxo-isopropylidene-shikimic acid].

AbstractAIM:
To study the effect of 3,4-oxo-isopropylidene-shikimic acid (ISA) against arteriovenous shunt and middle cerebral artery thrombosis (MCAT) in rats.
METHODS:
Arteriovenous shunt model was adopted to measure thrombus weight; The neurologic deficit (ND) and the infarct size (IS) of the middle cerebral thrombosis (MCAT) model induced by FeCl3 were observed; The effect of ISA on platelet aggregation rate of rat and rabbit by giving ISA in vivo and in vitro was studied.
RESULTS:
ISA 25, 50, 100 and 200 mg.kg-1 ig was shown to reduced the weight of thrombus in arteriovenous shunt model; ISA 50, 100 and 200 mg.kg-1 ig for 2 times in 24 hours, attenuated the ND of rats subjected to MCAT; ISA 100 and 200 mg.kg-1 reduced IS of rats after MCAT by 27.8% and 31.6%, respectively; ISA 50, 100 and 200 mg.kg-1 ig inhibited platelet aggregation of normal rats; ISA 10(-3)-10(-5) mol.L-1, inhibited rabbit platelet aggregation in vitro.
CONCLUSION:
ISA inhibited thrombosis by anti-platelet-aggregation.
AuthorsHong-tao Wang, Hong-tao Jin, Jian-ning Sun, Qiu-ping Xu, Ya-jian Guo
JournalYao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 37 Issue 4 Pg. 245-8 (Apr 2002) ISSN: 0513-4870 [Print] China
PMID12579816 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 3,4-oxoisopropylideneshikimic acid
  • Fibrinolytic Agents
  • Shikimic Acid
Topics
  • Animals
  • Brain (pathology)
  • Disease Models, Animal
  • Fibrinolytic Agents (pharmacology, therapeutic use)
  • Infarction, Middle Cerebral Artery (blood, pathology, prevention & control)
  • Male
  • Platelet Aggregation (drug effects)
  • Rabbits
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Shikimic Acid (analogs & derivatives, chemistry, isolation & purification)

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