Abstract | AIM: METHODS: Arteriovenous shunt model was adopted to measure thrombus weight; The neurologic deficit (ND) and the infarct size (IS) of the middle cerebral thrombosis (MCAT) model induced by FeCl3 were observed; The effect of ISA on platelet aggregation rate of rat and rabbit by giving ISA in vivo and in vitro was studied. RESULTS: ISA 25, 50, 100 and 200 mg.kg-1 ig was shown to reduced the weight of thrombus in arteriovenous shunt model; ISA 50, 100 and 200 mg.kg-1 ig for 2 times in 24 hours, attenuated the ND of rats subjected to MCAT; ISA 100 and 200 mg.kg-1 reduced IS of rats after MCAT by 27.8% and 31.6%, respectively; ISA 50, 100 and 200 mg.kg-1 ig inhibited platelet aggregation of normal rats; ISA 10(-3)-10(-5) mol.L-1, inhibited rabbit platelet aggregation in vitro. CONCLUSION: ISA inhibited thrombosis by anti-platelet-aggregation.
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Authors | Hong-tao Wang, Hong-tao Jin, Jian-ning Sun, Qiu-ping Xu, Ya-jian Guo |
Journal | Yao xue xue bao = Acta pharmaceutica Sinica
(Yao Xue Xue Bao)
Vol. 37
Issue 4
Pg. 245-8
(Apr 2002)
ISSN: 0513-4870 [Print] China |
PMID | 12579816
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 3,4-oxoisopropylideneshikimic acid
- Fibrinolytic Agents
- Shikimic Acid
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Topics |
- Animals
- Brain
(pathology)
- Disease Models, Animal
- Fibrinolytic Agents
(pharmacology, therapeutic use)
- Infarction, Middle Cerebral Artery
(blood, pathology, prevention & control)
- Male
- Platelet Aggregation
(drug effects)
- Rabbits
- Random Allocation
- Rats
- Rats, Wistar
- Shikimic Acid
(analogs & derivatives, chemistry, isolation & purification)
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