[Effect of tripterygium polyglucoside on T-lymphocyte subsets and serum interleukin-5 level in asthma patients].

Abstract

OBJECTIVE:

To investigate the therapeutic mechanism of Tripterygium polyglucoside (TII) in treating asthma patients.

METHODS:

Thirty asthma patients of middle or sever leoel were selected and randomly divided into three groups, Group A treated with TII, Group B treated with prednisone and Group C, the control group. Their peripheral CD4+, CD8+ T-lymphocytes were counted by flow cytometer and serum interleukin-5 (IL-5) level determined by ELISA before and after 4 weeks' treatment.

RESULTS:

In Group A, after treatment, CD4+ T-lymphocytes reduced from 0.462 +/- 0.035 to 0.426 +/- 0.039 (P < 0.01), CD8+ increased from 0.201 +/- 0.045 to 0.253 +/- 0.043 (P < 0.01), and serum IL-5 median concentration reduced from 65.3 ng/L to 10.9 ng/L (P < 0.01). Similar results was revealed in Group B, while there was insignificant change of the parameters in Group C. The serum concentration of IL-5 was positively correlated with the peripheral CD4+ count (r = 0.61, P < 0.01).

CONCLUSION:

TII is highly effective in treating asthma through regulating T-lymphocyte subset disorder and inhibiting production of IL-5.

• Authors: X H Wang, Z Y Zhang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 21 Issue 1 Pg. 25-7 (Jan 2001) ISSN: 1003-5370 [Print] China
• PMID: 12577372 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Diterpenes
• Drugs, Chinese Herbal
• Epoxy Compounds
• Glucosides
• Immunosuppressive Agents
• Interleukin-5
• Phenanthrenes
• triptolide

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Asthma (blood, immunology)
• CD4-CD8 Ratio
• Diterpenes (therapeutic use)
• Drugs, Chinese Herbal (therapeutic use)
• Epoxy Compounds
• Female
• Glucosides (therapeutic use)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Interleukin-5 (blood)
• Male
• Middle Aged
• Phenanthrenes
• Phytotherapy
• T-Lymphocyte Subsets (immunology)
• Tripterygium (chemistry)