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[Effect of tripterygium polyglucoside on T-lymphocyte subsets and serum interleukin-5 level in asthma patients].

AbstractOBJECTIVE:
To investigate the therapeutic mechanism of Tripterygium polyglucoside (TII) in treating asthma patients.
METHODS:
Thirty asthma patients of middle or sever leoel were selected and randomly divided into three groups, Group A treated with TII, Group B treated with prednisone and Group C, the control group. Their peripheral CD4+, CD8+ T-lymphocytes were counted by flow cytometer and serum interleukin-5 (IL-5) level determined by ELISA before and after 4 weeks' treatment.
RESULTS:
In Group A, after treatment, CD4+ T-lymphocytes reduced from 0.462 +/- 0.035 to 0.426 +/- 0.039 (P < 0.01), CD8+ increased from 0.201 +/- 0.045 to 0.253 +/- 0.043 (P < 0.01), and serum IL-5 median concentration reduced from 65.3 ng/L to 10.9 ng/L (P < 0.01). Similar results was revealed in Group B, while there was insignificant change of the parameters in Group C. The serum concentration of IL-5 was positively correlated with the peripheral CD4+ count (r = 0.61, P < 0.01).
CONCLUSION:
TII is highly effective in treating asthma through regulating T-lymphocyte subset disorder and inhibiting production of IL-5.
AuthorsX H Wang, Z Y Zhang
JournalZhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 21 Issue 1 Pg. 25-7 (Jan 2001) ISSN: 1003-5370 [Print] China
PMID12577372 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Diterpenes
  • Drugs, Chinese Herbal
  • Epoxy Compounds
  • Glucosides
  • Immunosuppressive Agents
  • Interleukin-5
  • Phenanthrenes
  • triptolide
Topics
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Asthma (blood, immunology)
  • CD4-CD8 Ratio
  • Diterpenes (therapeutic use)
  • Drugs, Chinese Herbal (therapeutic use)
  • Epoxy Compounds
  • Female
  • Glucosides (therapeutic use)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Interleukin-5 (blood)
  • Male
  • Middle Aged
  • Phenanthrenes
  • Phytotherapy
  • T-Lymphocyte Subsets (immunology)
  • Tripterygium (chemistry)

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