[Effect of tripterygium polyglucoside on T-lymphocyte subsets and serum interleukin-5 level in asthma patients].

To investigate the therapeutic mechanism of Tripterygium polyglucoside (TII) in treating asthma patients.
Thirty asthma patients of middle or sever leoel were selected and randomly divided into three groups, Group A treated with TII, Group B treated with prednisone and Group C, the control group. Their peripheral CD4+, CD8+ T-lymphocytes were counted by flow cytometer and serum interleukin-5 (IL-5) level determined by ELISA before and after 4 weeks' treatment.
In Group A, after treatment, CD4+ T-lymphocytes reduced from 0.462 +/- 0.035 to 0.426 +/- 0.039 (P < 0.01), CD8+ increased from 0.201 +/- 0.045 to 0.253 +/- 0.043 (P < 0.01), and serum IL-5 median concentration reduced from 65.3 ng/L to 10.9 ng/L (P < 0.01). Similar results was revealed in Group B, while there was insignificant change of the parameters in Group C. The serum concentration of IL-5 was positively correlated with the peripheral CD4+ count (r = 0.61, P < 0.01).
TII is highly effective in treating asthma through regulating T-lymphocyte subset disorder and inhibiting production of IL-5.
AuthorsX H Wang, Z Y Zhang
JournalZhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 21 Issue 1 Pg. 25-7 (Jan 2001) ISSN: 1003-5370 [Print] China
PMID12577372 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Diterpenes
  • Drugs, Chinese Herbal
  • Epoxy Compounds
  • Glucosides
  • Immunosuppressive Agents
  • Interleukin-5
  • Phenanthrenes
  • triptolide
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Asthma (blood, immunology)
  • CD4-CD8 Ratio
  • Diterpenes (therapeutic use)
  • Drugs, Chinese Herbal (therapeutic use)
  • Epoxy Compounds
  • Female
  • Glucosides (therapeutic use)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Interleukin-5 (blood)
  • Male
  • Middle Aged
  • Phenanthrenes
  • Phytotherapy
  • T-Lymphocyte Subsets (immunology)
  • Tripterygium (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: