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[Effect of guizhi decoction on adenyl cyclase and phosphodiesterase in hypothalamus of rats models of fever and hypothermia].

AbstractOBJECTIVE:
To observe the effect of Guizhi Decoction (GZD) on adenyl cyclase (AC) and phosphodiesterase (PDE) activities in hypothalamus of rat models of fever and hypothermia.
METHODS:
The AC and PDE activities in hypothalamus were determined using radio-isotope method.
RESULTS:
GZD could lower the AC activity in yeast induced fever rat model (P < 0.05), but cause rise of AC activity in aminopyrine induced hypothermia model (P < 0.05). No significant influence of GZD on PDE activity was shown in both fever or hypothermia models.
CONCLUSION:
The bi-directional thermo-regulation effect of GZD might be partially due to influence on AC activity.
AuthorsY Qi, H R Huo, J L Tian
JournalZhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 21 Issue 3 Pg. 203-5 (Mar 2001) ISSN: 1003-5370 [Print] China
PMID12577339 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • Phosphoric Diester Hydrolases
  • Adenylyl Cyclases
Topics
  • Adenylyl Cyclases (metabolism)
  • Animals
  • Body Temperature Regulation (drug effects)
  • Drugs, Chinese Herbal (pharmacology)
  • Fever (enzymology)
  • Hypothalamus (enzymology)
  • Hypothermia (enzymology)
  • Male
  • Phosphoric Diester Hydrolases (metabolism)
  • Phytotherapy
  • Rats
  • Rats, Wistar

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