Abstract | UNLABELLED: MATERIAL AND METHODS: Male rabbits (2.5-3.5 kg) were used. Acute myocardial ischemia was induced by occlusion of the left anterior descending coronary artery. tRNA and aminoacyl- tRNA synthetases were isolated from normal (control) rabbit liver 6, 12 and 24 h after experimental myocardial ischemia in autumn (the months of September and October) and winter (the months of December and January). The acceptor activity of tRNA and activity of alanyl- and lysyl- tRNA synthetases were determined using 14C-labelled amino acids alanine and lysine. RESULTS: The results of study show that acceptor activity of rabbit liver tRNA for alanine and lysine under 6, 12 and 24 h experimental myocardial ischemia in autumn is higher by 18-52 percent than in winter. Activities of rabbit liver alanyl- and lysyl- tRNA synthetases under 6, 12 and 24 h experimental myocardial ischemia in autumn is less by 15-35 percent than in winter. No differences in activity of tRNA and aminoacyl- tRNA synthetases between normal groups of both seasons were observed. CONCLUSIONS:
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Authors | Hiliaras Rodovicius |
Journal | Medicina (Kaunas, Lithuania)
(Medicina (Kaunas))
Vol. 39
Issue 1
Pg. 62-7
( 2003)
ISSN: 1010-660X [Print] Switzerland |
Vernacular Title | Triusiu kepenu tRNR ir aminoacil-tRNR-sintetaziu aktyvumas miokardo isemijos metu skirtingu metu laikotarpiu |
PMID | 12576767
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- RNA, Transfer
- Amino Acyl-tRNA Synthetases
- Lysine-tRNA Ligase
- Lysine
- Alanine
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Topics |
- Alanine
(metabolism)
- Amino Acyl-tRNA Synthetases
(metabolism)
- Animals
- Liver
(enzymology, metabolism)
- Lysine
(metabolism)
- Lysine-tRNA Ligase
(metabolism)
- Male
- Myocardial Ischemia
(metabolism)
- Protein Biosynthesis
- RNA, Transfer
(metabolism)
- Rabbits
- Seasons
- Time Factors
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