Effects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats.

Abstract

Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induced increases in 5-HT synthesis and TPH expression in the dorsal raphe were shown to be suppressed by Paeonia radix treatment; 5-HT synthesis and TPH expression were inhibited by Paeonia radix treatment under resting conditions as well. In sum, treatment with Paeonia radix, inhibiting 5-HT synthesis and TPH expression, may bring about reduced fatigue, both during exercise and the resting state.

• Authors: Jung-Ae Hong, Seok-Hee Chung, Jong-Soo Lee, Sung-Soo Kim, Hyun-Dae Shin, Hong Kim, Mi-Hyeon Jang, Taeck-Hyun Lee, Baek-Vin Lim, Young-Pyo Kim, Chang-Ju Kim
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 26 Issue 2 Pg. 166-9 (Feb 2003) ISSN: 0918-6158 [Print] Japan
• PMID: 12576675 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Plant Extracts
• Serotonin
• Tryptophan Hydroxylase

Topics

• Animals
• Dose-Response Relationship, Drug
• Exercise Test (methods)
• Gene Expression Regulation, Enzymologic (drug effects, physiology)
• Male
• Paeonia
• Physical Conditioning, Animal (methods)
• Plant Extracts (pharmacology)
• Raphe Nuclei (drug effects, metabolism)
• Rats
• Rats, Sprague-Dawley
• Serotonin (biosynthesis)
• Tryptophan Hydroxylase (biosynthesis)