Sensitizing capacity of two monomeric aldehyde components in p-tert-butylphenol-formaldehyde resin.

Abstract

Contact allergy to p-tert-butylphenol-formaldehyde resin is not rare. This resin consists of a large number of substances, most of which are unknown. For diagnostic and preventive reasons, the chemical identity of the sensitizers should be known as well as their sensitizing capacities, cross-reaction patterns and presence in the environment. The aim of this study was to investigate the sensitizing capacities and cross-reaction patterns for 5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzaldehyde and 5-tert-butyl-2-hydroxy-benzaldehyde in the guinea pig maximization test. 2,6-Dimethylol p-tert-butylphenol, p-tert-butylcate chol, 2-methylol p-tert-butylphenol, p-tert-butylphenol, 4-tert-butyl-2-(5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzyloxymethyl)-6-hydroxymethyl-phenol and 4-tert-butyl-2-(5-tert-butyl-2-hydroxy-benzyloxymethyl)-phenol were used as potential cross-reacting substances. 5-tert-Butyl-2-hydroxy-3-hydroxymethyl-benzaldehyde was shown to be a sensitizer (p = 0.041). In animals induced with this compound no cross-reactions to the putative cross-reacting substances were seen. In contrast, 5-tert-butyl-2-hydroxy-benzaldehyde failed to induce sensitization and no cross-reactions were detected.

• Authors: Erik Zimerson, Magnus Bruze
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 82 Issue 6 Pg. 418-22 ( 2002) ISSN: 0001-5555 [Print] Sweden
• PMID: 12575846 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Allergens
• Resins, Synthetic
• p-tert-butylphenolformaldehyde resin

Topics

• Allergens (adverse effects)
• Animals
• Chromatography, High Pressure Liquid
• Cross Reactions (immunology)
• Dermatitis, Allergic Contact (etiology, immunology)
• Female
• Guinea Pigs
• Intradermal Tests (methods)
• Models, Animal
• Resins, Synthetic (adverse effects)