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[The place of new antihistamines in allergy management. Apropos of desloratadine].

Abstract
Desloratadine, the active metabolite of loratadine, is a new antihistamine. Because of its anti allergy properties, desloratidine has an affinity for histamine receptors 25 to 100 times greater to those of the usual antihistamines, coupled with a capacity to inhibit the production of pro-inflammatory mediators. When evaluated in healthy volunteers, the half life of desloratadine has been estimated at 27 hours, which is comparable with a night time length of action. Many clinical studies made with patients suffering with allergic rhinitis or chronic idiopathic urticaria have shown a rapid symptom reduction, lasting 24 hours after first taking. This action was correlated with an improvement in socio-professional activity, sleep and quality of life in general. In patients suffering from allergic rhinitis, rhinomanometry showed a significant improvement in nasal congestion by desloratadine. The clinical advantages of desloratadine on antihistamines taken previously were measured in a study made on almost 48,000 patients, of whom 91% found its efficacity satisfactory. By its powerful action, coupled with an excellent tolerance profile, desloratadine represents a real therapeutic advance for allergic patients.
AuthorsA Sabbah
JournalAllergie et immunologie (Allerg Immunol (Paris)) Vol. 34 Issue 10 Pg. 377-83 (Dec 2002) ISSN: 0397-9148 [Print] France
Vernacular TitlePlace des nouveaux antihistaminiques dans la prise en charge de l'allergie: à propos de la desloratadine.
PMID12575624 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Anti-Allergic Agents
  • Histamine H1 Antagonists
  • Inflammation Mediators
  • Recombinant Proteins
  • Intercellular Adhesion Molecule-1
  • Loratadine
  • desloratadine
Topics
  • Anti-Allergic Agents (adverse effects, pharmacology, therapeutic use)
  • Double-Blind Method
  • Half-Life
  • Histamine H1 Antagonists (adverse effects, pharmacology, therapeutic use)
  • Histamine Release (drug effects)
  • Humans
  • Hypersensitivity, Immediate (drug therapy)
  • Inflammation Mediators (antagonists & inhibitors)
  • Intercellular Adhesion Molecule-1 (drug effects)
  • Liver (metabolism)
  • Loratadine (adverse effects, analogs & derivatives, pharmacology, therapeutic use)
  • Meta-Analysis as Topic
  • Multicenter Studies as Topic
  • Patient Acceptance of Health Care
  • Randomized Controlled Trials as Topic
  • Recombinant Proteins (drug effects)
  • Rhinitis, Allergic, Perennial (drug therapy)
  • Rhinitis, Allergic, Seasonal (drug therapy)
  • Safety
  • Treatment Outcome
  • Urticaria (drug therapy)

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