[Effect of qiongyugao on the action of DDP in inhibiting the division of GLC-82 cell strain in vitro].

Abstract

OBJECTIVE:

To observe the effect of Qiongyugao (QYG) on the action of DDP in inhibiting the division of GLC-82 cell strain in vitro.

METHODS:

The method of serum pharmacology was used in observing the morphological change of the cancer cells. By accounting the number of the live cells of each day during 6 days respectively, the growth curve was drawn up. The effects of the three groups on the cancer cells apoptosis of GLC-82 cell strain were analysed by FACS. RESULLTS: The growth of the cancer cells in control group (normal saline) was much better than the other two groups; in chemical therapy group (DDP), the number of the live cells almost kept steady; the number of the live cells in combined group(DDP plus QYG) became even lower. QYG could enhance the action of DDP in inducing the apoptosis of GLC-82 cells strain remarkably.

CONCLUSION:

QYG can enhance the effects of chemotherapy in inhibiting cancer cells division and inducing their apoptosis.

• Authors: Q Zhang, Q Xie, X Chen, L Sun, K Ye, C Tang
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 23 Issue 11 Pg. 694-6 (Nov 2000) ISSN: 1001-4454 [Print] China
• PMID: 12575261 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Cisplatin

Topics

• Adenocarcinoma (pathology)
• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Antineoplastic Combined Chemotherapy Protocols (pharmacology)
• Apoptosis (drug effects)
• Cell Division (drug effects)
• Cisplatin (pharmacology)
• Drugs, Chinese Herbal (pharmacology)
• Flow Cytometry
• Lung Neoplasms (pathology)
• Male
• Rats
• Rats, Sprague-Dawley
• Tumor Cells, Cultured