[Effects of nao-yi-an granule on bcl-2 expression in the rat brain after experimental cerebral hemorrhage].

Abstract

OBJECTIVE:

To investigate the protective effects and mechanisms of the traditional Chinese medicine complex, nao-yi-an granule (NYA) on experimental intracerebral hemorrhage (ICH) in rats.

METHODS:

ICH models anesthesized were induced by stereotaxical injection of 2 microliters normal saline containing 0.4 U bacterial collagenase(type VII) into the right globas pallidus(GP), and the protein expression of bcl-2 in the rat brain after ICH was detected with the immunohistochemistry method, with which the effects of NYA were observed.

RESULTS:

Bcl-2 positive cells were found in the cerebral cortex and basal ganglia area after ICH. Immunoreactivity was localized in the cytoplasm as a fine granular precipitate. The levels of bcl-2 expression in the model group varied at different time-points, and reached the peak at 2 d. In the NYA group, the protein expression of bcl-2 was increased significantly both in the cortex and in the basal ganglia compared with those in the model group.

CONCLUSION:

NYA can significantly upregulate the protein expression of bcl-2.

• Authors: Hua-xian Zhang, Xing-qun Li, Tao Tang
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 27 Issue 1 Pg. 38-40 (Feb 28 2002) ISSN: 1000-5625 [Print] China
• PMID: 12575231 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Neuroprotective Agents
• Proto-Oncogene Proteins c-bcl-2

Topics

• Animals
• Brain (metabolism)
• Drugs, Chinese Herbal (pharmacology)
• Intracranial Hemorrhages (genetics, metabolism)
• Male
• Neuroprotective Agents (pharmacology)
• Proto-Oncogene Proteins c-bcl-2 (biosynthesis, genetics)
• Random Allocation
• Rats
• Rats, Sprague-Dawley