[Studies on Euphorbia fischeriana diterpenoide lactones inhibitory effect on human tumor cells in vitro].

Abstract

In this paper, two diterpenoide lactones 16-hydroxypseudojolkinolide B and jolkinolide B were isolated from Euphorbia fischeriana Steud. They showed inhibitory effect on human tumor cells both the K562 cell and CNE2 cell and significant dose-effect relationship. The IC50 values of 16-hydroxypseudojolkinolide B on the two human tumor cells were near to that of ADM's.

• Authors: W Liu, F He, Z Ruan, X Gu, X Wu, G Qin
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 23 Issue 10 Pg. 623-5 (Oct 2000) ISSN: 1001-4454 [Print] China
• PMID: 12575039 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 16-hydroxypseudojolkinolide B
• Antineoplastic Agents, Phytogenic
• Diterpenes
• Drugs, Chinese Herbal
• jolkinolide B

Topics

• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Cell Division (drug effects)
• Diterpenes (isolation & purification, pharmacology)
• Dose-Response Relationship, Drug
• Drugs, Chinese Herbal (isolation & purification, pharmacology)
• Euphorbia (chemistry)
• Humans
• K562 Cells
• Nasopharyngeal Neoplasms (pathology)
• Tumor Cells, Cultured