[Efficacy of albendazole immunoliposome against echinococcosis granulosus in mice].

Abstract

OBJECTIVE:

To evaluate the effect of albendazole immunoliposome (IL-Alb) against Echinococcus granulosus.

METHODS:

Mice infected with protoscolices of E. granulosus were divided into five groups. Four groups were treated with albendazole (Alb), albendazole liposome (L-Alb), albendazole sulfoxide liposome (L-Albso), and IL-Alb respectively at a dosage of 100 mg (Alb)/(kg.d) x 5 d for 3 courses. The fifth group was established as control. The major criteria for evaluating the effects included a reduction rate of E. granulosus tissue wet weight, histopathological examination of the cysts by both light microscopy and electron-microscopy, and the content of albendazole-sulfoxide in cysts detected by HPLC.

RESULTS:

The efficacy of albendazole immunoliposome was significantly higher than that of albendazole liposome, and much higher than that of albendazole. The reduction rates of cyst tissue weight of IL-Alb group, L-Alb group and Alb group were 91.5%, 80.3%, 61.2% respectively as compared to control group; the concentration of Albso in cyst tissue of the above groups were 5.15 micrograms/g, 2.18 micrograms/g, 0.76 microgram/g respectively (P < 0.01). The histopathological damages of cysts were also found most severely in the group of IL-Alb.

CONCLUSION:

Immunoliposome as a targeting carrier may significantly strengthen the therapeutic effect of albendazole on echinococcosis granulosus.

• Authors: R L Niu, H X Xue, H M Mo
• Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) Vol. 19 Issue 3 Pg. 141-4 ( 2001) ISSN: 1000-7423 [Print] China
• PMID: 12571937 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Liposomes
• Albendazole

Topics

• Albendazole (administration & dosage)
• Animals
• Anthelmintics (administration & dosage)
• Echinococcosis (drug therapy)
• Female
• Liposomes
• Mice
• Mice, Inbred Strains
• Treatment Outcome