Fullerene derivative attenuates ischemia-reperfusion-induced lung injury.

Abstract

Reactive oxygen species are the major contributing factors to lung ischemia-reperfusion (IR) injury. In this study, we tested whether a water soluble antioxidant fullerene derivative [C(60)(ONO(2))(7 +/- 2)] attenuates IR lung injury. Young Wistar rats were divided into two groups: control and C(60)(ONO(2))(7 +/- 2). Under ventilation with 95% air-5% CO(2) gas mixture and a 2.5 cm H(2)O end-expiratory pressure, the isolated lungs were perfused with a physiological solution. The experimental protocol included three periods: baseline (10 min), ischemia (45 min) and reperfusion (60 min, ventilated with 95% O(2)-5% CO(2) gas mixture). Before and after ischemia, we measured pulmonary arterial pressure (Ppa), pulmonary venous pressure and lung weight (W). Then, pulmonary capillary pressure and filtration coefficient (K(fc)) were calculated. Ischemia caused increases in Ppa, W and K(fc) in the control group. For most cases, the above ischemia-induced increases were attenuated by the C(60)(ONO(2))(7 +/- 2) pretreatment. Our results suggest that the antioxidant C(60)(ONO(2))(7 +/- 2) attenuates IR-induced lung injury.

• Authors: Y-L Lai, P Murugan, K C Hwang
• Journal: Life sciences (Life Sci) Vol. 72 Issue 11 Pg. 1271-8 (Jan 31 2003) ISSN: 0024-3205 [Print] Netherlands
• PMID: 12570927 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Fullerenes

Topics

• Animals
• Antioxidants (therapeutic use)
• Blood Pressure (drug effects)
• Fullerenes (therapeutic use)
• Ischemia (drug therapy, physiopathology)
• Lung (blood supply)
• Rats
• Rats, Wistar
• Reperfusion Injury (drug therapy, physiopathology)
• Vascular Resistance (drug effects)