[Target chemotherapy of intestinal nematode infection in area with low endemicity].

Abstract

OBJECTIVE:

To evaluate the control measures for intestinal nematodiasis in endemic area with low prevalence and intensity of infection.

METHODS:

Target chemotherapy was carried out in high-risk population based on the epidemiological characteristics such as age and clinical findings. Albendazole and mebendazole were administered each 200 mg once daily every year for 3 or 5 years. Saturated brine floatation and Kato-Katz thick smear techniques were used for stool examination to evaluate the efficacy of treatment.

RESULTS:

Two hundred residents from each of the three investigation villages were selected for target chemotherapy once a year for three years. The prevalence of intestinal nematodes decreased from 6.2% in 1995 to 5.4% in 1996 and 3.2% in 1997, and remained at 2.3% after three years in 2000. One control village where only primary school students were treated once a year for 5 years, the prevalence of Ascaris and Trichuris infection also decreased from 1.4% and 4.2% in 1995 to 0.9% and 1.4% in 2000, respectively. The target chemotherapy on the predisposed population to hookworm infection showed that the prevalence in the population above 41 years old was declined from 19.4% to 10.9%.

CONCLUSION:

The target chemotherapy is an economical and effective approach for the control of intestinal nematode infection in endemic area with low prevalence and intensity of infection.

• Authors: Tao Zhang, Yi-ping Shen, Ying Liu, Wei-ping Yang, Jing-ou Shao, Shao-you Ju, Kai Dong, Ju-ling Xu, Ji-min Jiang
• Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) Vol. 20 Issue 3 Pg. 174-6 ( 2002) ISSN: 1000-7423 [Print] China
• PMID: 12568001 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antinematodal Agents
• Mebendazole
• Albendazole

Topics

• Adult
• Aged
• Albendazole (administration & dosage)
• Antinematodal Agents (administration & dosage)
• Drug Therapy, Combination
• Evaluation Studies as Topic
• Humans
• Intestinal Diseases, Parasitic (drug therapy, epidemiology)
• Mebendazole (administration & dosage)
• Middle Aged
• Nematode Infections (drug therapy, epidemiology)
• Prevalence
• Treatment Outcome