Impact of posterior GPI pallidotomy on leg tremor in Parkinson's disease.

Abstract

Although stereotactic thalamotomy is the mainstay in the surgical treatment of tremor in patients with Parkinson's disease (PD), this surgery is not favored and is even a matter of potential concern in the treatment of leg tremor since it carries a significant risk of injury to the internal capsule. In this study we have carried out a quantitative assessment of leg tremor alleviation in 12 patients with PD after MRI-/microelectrode-guided stereotactic ablation of the posterior part of the globus pallidus internus (GPi). The results showed that posterior GPi pallidotomy combined with drug therapy is a satisfactorily effective therapeutic strategy to treat parkinsonian leg tremor.

• Authors: Satoshi Goto, Shigeyuki Nishikawa, Shuji Mita, Yukitaka Ushio
• Journal: Stereotactic and functional neurosurgery (Stereotact Funct Neurosurg) Vol. 78 Issue 2 Pg. 64-9 ( 2002) ISSN: 1011-6125 [Print] Switzerland
• PMID: 12566832 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 S. Karger AG, Basel

Topics

• Globus Pallidus (surgery)
• Humans
• Leg (physiopathology)
• Magnetic Resonance Imaging (methods)
• Middle Aged
• Neuronavigation (methods)
• Parkinson Disease (physiopathology, surgery)
• Tremor (physiopathology, surgery)