LIS1 at the microtubule plus end and its role in dynein-mediated nuclear migration.

Abstract

The cytoplasmic dynein complex and its accessory dynactin complex are involved in many cellular activities including nuclear migration in fungi (for review see Karki and Holzbaur, 1999). LIS1, the product of a causal gene for human lissencephaly (smooth brain), has also been implicated in dynein function based on studies in fungi and more recent studies in higher eukaryotic systems (for review see Gupta et al., 2002). Exactly how LIS1 may regulate the behavior of cytoplasmic dynein in various organisms is a fascinating question. In this issue, Lee et al. (2003) describe important new findings in Saccharomyces cerevisiae regarding the role of LIS1 (Pac1) in dynein-mediated nuclear migration.

• Authors: Xin Xiang
• Journal: The Journal of cell biology (J Cell Biol) Vol. 160 Issue 3 Pg. 289-90 (Feb 03 2003) ISSN: 0021-9525 [Print] United States
• PMID: 12566423 (Publication Type: Journal Article, Review, Comment)

Chemical References

• Microtubule-Associated Proteins
• Dyneins

Topics

• Cell Movement (physiology)
• Cell Nucleus (metabolism, ultrastructure)
• Dyneins (metabolism)
• Microtubule-Associated Proteins (metabolism)
• Microtubules (metabolism)
• Mitosis (physiology)
• Saccharomyces cerevisiae (cytology, metabolism)
• Spindle Apparatus (metabolism)