In vivo characterization of A-192411: a novel fungicidal lipopeptide (II).

Abstract

The ability of the novel antifungal cyclic hexalipopetide A-192411 to treat fungal infections in rodents is presented. Efficacy was demonstrated against Candida albicans as both prolonged survival of systemically infected mice and clearance of viable yeasts from kidneys. The efficacy of A-192411, administered intraperitoneally, was equivalent to amphotercin B at a 4-fold lower dose by weight in the systemic candidiasis models in mice, while the efficacy of A-192441 administered intravenously was equivalent to amphotercin B by weight in the Candida pyelonephritis model in rats. A-192411 also slightly prolonged the survival of immunocompromised mice infected systemically with Aspergillus fumigatus.

• Authors: Jonathan A Meulbroek, Angela M Nilius, Qun Li, Weibo Wang, Lisa Hasvold, Beth Steiner, Daniel A Dickman, Hong Ding, David Frost, Robert C Goldman, Paul Lartey, Jacob J Plattner, Youssef L Bennani
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 13 Issue 3 Pg. 495-7 (Feb 10 2003) ISSN: 0960-894X [Print] England
• PMID: 12565958 (Publication Type: Journal Article)

Chemical References

• A-192411
• Antifungal Agents
• Oligopeptides
• Amphotericin B

Topics

• Amphotericin B (therapeutic use)
• Animals
• Antifungal Agents (therapeutic use)
• Aspergillosis (drug therapy, microbiology)
• Aspergillus fumigatus
• Candida albicans
• Candidiasis (drug therapy, microbiology)
• Drug Resistance, Fungal
• Immunocompromised Host
• Kidney (drug effects, microbiology)
• Mice
• Oligopeptides (chemical synthesis, pharmacology)
• Rats
• Survival Analysis