Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: We developed a novel heterotopic cardiac transplantation-coronary ligation model capable of inducing myocardial infarction in the absence of downstream hemodynamic effects, and allowing differential quantification of indexes of cardiac remodeling in vivo, such as the local and remote effects of angiotensin II and TNF-alpha on cardiac remodeling. Modification of activated cytokines, such as TNF-alpha induced by cardiac ischemic stress, might be a beneficial strategy for the treatment of cardiac dysfunction and subsequent cardiac remodeling after acute myocardial infarction.
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Authors | Hiroshi Nakamura, Satoko Takata, Seiji Umemoto, Masunori Matsuzaki |
Journal | Journal of cardiology
(J Cardiol)
Vol. 41
Issue 1
Pg. 41-2
(Jan 2003)
ISSN: 0914-5087 [Print] Netherlands |
PMID | 12564114
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Tumor Necrosis Factor-alpha
- Angiotensin II
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Topics |
- Angiotensin II
(metabolism)
- Animals
- Heart Transplantation
- Myocardial Infarction
(pathology, physiopathology)
- Rats
- Rats, Inbred Lew
- Tissue Donors
- Transplantation, Heterotopic
- Tumor Necrosis Factor-alpha
(metabolism)
- Ventricular Function, Left
- Ventricular Remodeling
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