Results of long-term carcinogenicity bioassays on tert-amyl-methyl-ether (TAME) and di-isopropyl-ether (DIPE) in rats.

Abstract

Tert-amyl-methyl ether (TAME) was administered by gavage in extra virgin olive oil solution at concentrations of 750, 250, or 0 mg/kg bw to groups of 100 male and 100 female Sprague-Dawley rats 8 weeks old at the start of the experiment. Di-isopropyl ether (DIPE) was administered in the same manner at the doses of 1000, 250, or 0 mg/kg body weight to groups of 100 male and 100 female Sprague-Dawley rats. TAME and DIPE were each delivered in 1-mL solution 4 days a week for 78 weeks. Control animals received 1 mL of extra virgin olive oil without TAME or DIPE. At the end of the treatment period, all animals were kept under observation until spontaneous death. Under these test conditions, TAME and DIPE were found to be potential carcinogenic agents for various organs and tissues.

• Authors: Fiorella Belpoggi, Morando Soffritti, Franco Minardi, Luciano Bua, Elisa Cattin, Cesare Maltoni
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 982 Pg. 70-86 (Dec 2002) ISSN: 0077-8923 [Print] United States
• PMID: 12562629 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Air Pollutants
• Carcinogens
• Ethers
• Methyl Ethers
• tertiary-amyl methyl ether
• diisopropyl ether

Topics

• Air Pollutants (toxicity)
• Animals
• Biological Assay (methods)
• Carcinogens (toxicity)
• Ethers (toxicity)
• Female
• Male
• Methyl Ethers (toxicity)
• Neoplasms, Experimental (chemically induced, classification, pathology)
• Rats