Cartilage regeneration using slow release of bone morphogenetic protein-2 from a gelatin sponge to treat experimental canine tracheomalacia: a preliminary report.
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| Abstract |
We investigated whether saber sheath-type tracheomalacia could be treated by the slow release of bone morphogenetic protein (BMP)-2 from a gelatin sponge. A 1 cm gap was made in the middle portion of each of 10 consecutive tracheal cartilage rings in the canine cervix (control group, n = 3), then a gelatin sponge containing 12 microg of BMP-2 solution was implanted in the gap (12 microg group, n = 3). In another group (120 microg + P group, n = 3), the implanted gelatin sponge contained 120 microg of BMP-2 solution, and the gap was covered with periosteum. All of the control dogs developed saber sheath-type tracheomalacia, whereas tracheomalacia was not observed in the 12 microg and 120 microg + P groups. In the 12 microg group, fibrous cartilage was observed at the ends of the cartilage stumps. In the 120 microg + P group, newly formed bone and cartilage were observed to form a bridge between the cartilage stumps. The regeneration of cartilage or bone induced by the slow release of BMP-2 from a gelatin sponge might be useful for treatment of tracheomalacia.
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| Authors | Taku Okamoto, Yasumichi Yamamoto, Masashi Gotoh, Dage Liu, Minoru Kihara, Kotaro Kameyama, Eiichi Hayashi, Kenji Nakamura, Akira Yamauchi, Cheng-Long Huang, Hiroyasu Yokomise, Masaya Yamamoto, Tatsuo Nakamura, Yasuhiko Shimizu, Yasuhiko Tabata |
| Journal | ASAIO journal (American Society for Artificial Internal Organs : 1992) (ASAIO J) 2003 Jan-Feb Vol. 49 Issue 1 Pg. 63-9 ISSN: 1058-2916 [Print] United States |
| PMID | 12558309 (Publication Type: Journal Article) |
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