Enhanced growth rate of transplanted mammary adenocarcinoma induced in C3H mice by dietary linoleate.

Abstract

Three-month-old C3H female mice were given injections of 5-mg pieces of mammary adenocarcinoma and were then fed diets that either were fat free or contained saturated fat (15% hydrogenated cottonseed oil) or linoleate (1-15% corn oil). After 6 weeks, the tumors in mice fed the linoleate diet weighed 3-4 times more than those in mice fed the fat-free or saturated-fat diets. Despite a linoleate-free diet, tumors contained appreciable amounts of linoleate and arachidonate (approximately 2 and 9% of the total fatty acids, respectively). When the level of dietary corn oil was increased from 1 to 15%, the linoleate content of the tumors increased from 4 to 18% of the total fatty acids. However, in these instances, the tumor arachidonate levels increased to maximum values even when the 1% corn oil diet was used. These observations showed that mammary tumor growth was depressed by a fat-free or saturated-fat diet and enhanced by dietary linoleate. Furthermore, they suggested that the growth rate was related to the arachidonate content rather than the linoleate content of the tumors.

• Authors: G A Rao, S Abraham
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 56 Issue 2 Pg. 431-2 (Feb 1976) ISSN: 0027-8874 [Print] United States
• PMID: 1255775 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Arachidonic Acids
• Dietary Fats

Topics

• Animals
• Arachidonic Acids (metabolism)
• Dietary Fats (adverse effects)
• Female
• Mammary Neoplasms, Experimental (metabolism)
• Mice
• Mice, Inbred C3H