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The zinc glycinate marker in human colon carcinoma.

Abstract
In an attempt to identify new tumor markers in human colon carcinoma, we produced antisera in rabbits tolerant to normal human tissue antigens and immunized with zinc glycinate-treated extracts of liver metastases from a colon carcinoma. These antisera reacted with carcinoembryonic antigen and with an additional component present in the tumor extracts but not detected in the extracts of normal tissues. The new component, the zinc glycinate marker (ZGM), had an alpha2 mobility on immunoelectrophoresis, was soluble in 1 M perchloric acid, and had a molecular weight of approximately 2X10(6), as indicated by its elution pattern on Sepharose 6-B chromatography. It differed from alpha fetoprotein, nonspecific cross-reacting antigens (NCA, NGP, or CCA III), ferritin-like molecules, and blood group substances A, B, H, Lewis a, and Lewis b. The ZGM was similarly identified in saline or zinc glycinate extracts of 11 of 23 carcinomas of the colon. With routine hematoxylineosin staining, no histologic differences were apparent between tumors bearing the antigen and those without it.
AuthorsG Pusztaszeri, C A Saravis, N Zamcheck
JournalJournal of the National Cancer Institute (J Natl Cancer Inst) Vol. 56 Issue 2 Pg. 275-8 (Feb 1976) ISSN: 0027-8874 [Print] United States
PMID1255760 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, Neoplasm
  • Carcinoembryonic Antigen
  • Immune Sera
  • Zinc
Topics
  • Antigens, Neoplasm (analysis, isolation & purification)
  • Carcinoembryonic Antigen
  • Colonic Neoplasms (immunology)
  • Cross Reactions
  • Humans
  • Immune Sera
  • Liver Neoplasms (immunology)
  • Neoplasm Metastasis
  • Zinc

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