Abstract |
The paper describes the catalytic activity of butyrylcholinesterase (BuChE) measured in plasma, liver, white adipose tissue, heart, and brain of rats intraperitoneally administered a single non-lethal dose of cycloheximide (2.0 mg/kg body weight; CHM). The BuChE assay was performed on rats of both sexes either administered CHM or saline (controls), and killed 2, 3, 4, 5, 10 days later. A significant decrease of BuChE catalytic activity was observed in all tested tissues except plasma. In animals of both sexes, the lowest BuChE catalytic activity was found in the liver (2-6%), while it was higher in white adipose tissue, heart, and brain. However, the respective values remained significantly different from controls (33-67%, 49-62%, and 14-71% in males, and 24-82%, 72-86%, and 33-67% in females). Since there was no effect of CHM on BuChE catalytic activity in plasma, the data suggest that CHM inhibits the synthesis of BuChE rather than its active site.
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Authors | Ana Lucić, Vlasta Bradamante, Bozica Radić, Maja Peraica, Ana-Marija Domijan, Radovan Fuchs |
Journal | Arhiv za higijenu rada i toksikologiju
(Arh Hig Rada Toksikol)
Vol. 53
Issue 3
Pg. 185-90
(Sep 2002)
ISSN: 0004-1254 [Print] Croatia |
PMID | 12557470
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Enzyme Inhibitors
- Cycloheximide
- Butyrylcholinesterase
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Topics |
- Animals
- Antifungal Agents
(pharmacology)
- Butyrylcholinesterase
(metabolism)
- Cycloheximide
(pharmacology)
- Enzyme Inhibitors
(pharmacology)
- Female
- Male
- Rats
- Rats, Wistar
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