Variations in the human Th2-specific chemokine TARC gene.

Abstract

Th2-specific chemokine thymus and activation-regulated chemokine (TARC)/CC chemokine ligand (CCL)17 is highly implicated in the pathogenesis of Th-2-dominated allergic diseases such as bronchial asthma (BA) and atopic dermatitis (AD). We performed polymorphism screening of the coding and promoter regions of the TARC gene. We found two rare variations in the coding region of exon 3 (2134C>T and 2037G>A) and a single nucleotide polymorphism (SNP) in the 5'-flanking region (-431C>T). Individuals carrying the 431T allele showed significantly increased serum levels of TARC compared with those not carrying the 431T allele, suggesting that this SNP has functional significance. However, when the genotypes at the SNP site were determined for 158 healthy individuals, 105 patients with BA and 148 patients with AD, we observed no significant association of the SNP with susceptibility to BA or AD.

• Authors: Takashi Sekiya, Yuichiro Tsunemi, Misato Miyamasu, Ken Ohta, Atsushi Morita, Hidehisa Saeki, Kouji Matsushima, Osamu Yoshie, Naoyuki Tsuchiya, Masao Yamaguchi, Kazuhiko Yamamoto, Kunihiko Tamaki, Koichi Hirai
• Journal: Immunogenetics (Immunogenetics) Vol. 54 Issue 10 Pg. 742-5 (Jan 2003) ISSN: 0093-7711 [Print] United States
• PMID: 12557061 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CCL17 protein, human
• Chemokine CCL17
• Chemokines, CC

Topics

• Asthma (genetics)
• Base Sequence
• Chemokine CCL17
• Chemokines, CC (blood, genetics)
• Dermatitis, Atopic (genetics)
• Genetic Variation
• Humans
• Molecular Sequence Data
• Polymorphism, Single Nucleotide
• Th2 Cells (immunology)