Abstract | BACKGROUND: PATIENTS AND METHODS: The study comprised 154 healthy controls and 108 colorectal resections (79 curative, 15 palliative and 14 benign). Samples were collected at 4-6 hours, days 1,3,5,7 and 10 post surgery. RESULTS: Six-hour levels were significantly lower in the curative group (p < 0.0005) but not in the benign and palliative groups (p = 0.27 and 0.3, respectively). Sensitivity and specificity at 20% cut-off fall in VEGF gives 83.5% sensitivity with 80% specificity in predicting curative resection. CONCLUSION: Early postoperative serum VEGF levels show significant fall and may help to identify the oncological status of colorectal cancer resections.
|
Authors | Harish Kumar, Kamal Heer, Graeme S Duthie, John R T Monson |
Journal | Anticancer research
(Anticancer Res)
2002 Nov-Dec
Vol. 22
Issue 6B
Pg. 3717-22
ISSN: 0250-7005 [Print] Greece |
PMID | 12552982
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Endothelial Growth Factors
- Intercellular Signaling Peptides and Proteins
- Lymphokines
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
|
Topics |
- Adult
- Colorectal Neoplasms
(blood, blood supply, pathology, surgery)
- Endothelial Growth Factors
(blood)
- Female
- Humans
- Intercellular Signaling Peptides and Proteins
(blood)
- Lymphokines
(blood)
- Male
- Middle Aged
- Neoplasm Staging
- Neovascularization, Pathologic
(blood)
- Palliative Care
- Predictive Value of Tests
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
|