Lepirudin use in a neonate with heparin-induced thrombocytopenia.

Abstract

OBJECTIVE:

To describe a case of heparin-induced thrombocytopenia (HIT) in a premature infant and the doses of danaparoid and lepirudin needed to achieve appropriate therapeutic endpoints.

CASE SUMMARY:

A 30-week gestational age infant was diagnosed with HIT with heparin antibodies. Danaparoid 2.0-2.4 units/kg/h achieved anti-Xa levels of 0.2-0.4 U/mL, but thrombocytopenia failed to resolve. Lepirudin was started in place of danaparoid. Lepirudin doses of 0.03-0.05 mg/kg/h achieved target activated partial thromboplastin time values of 1.5-2.0 times baseline.

DISCUSSION:

Dosing information for danaparoid in neonates is limited, and information for lepirudin appears only in German literature at this time. HIT is well documented in newborns, and lepirudin use in these situations is likely to increase. This report provides some guidance for optimal dosing. It also provides some guidance for HIT evaluation in preterm infants, in whom blood volume for laboratory tests is a major issue.

CONCLUSIONS:

HIT is an important and potentially fatal problem in neonates. Lepirudin may be the drug of choice, especially since danaparoid is now unavailable. Initial lepirudin dosing should not exceed 0.05 mg/kg/h.

• Authors: Thuy N Nguyen, Peter Gal, J Laurence Ransom, Rita Carlos
• Journal: The Annals of pharmacotherapy (Ann Pharmacother) Vol. 37 Issue 2 Pg. 229-33 (Feb 2003) ISSN: 1060-0280 [Print] United States
• PMID: 12549954 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drug Combinations
• Hirudins
• Recombinant Proteins
• Dermatan Sulfate
• Heparin
• Chondroitin Sulfates
• Heparitin Sulfate
• danaparoid
• lepirudin

Topics

• Chondroitin Sulfates (therapeutic use)
• Dermatan Sulfate (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Combinations
• Heparin (adverse effects)
• Heparitin Sulfate (therapeutic use)
• Hirudins (analogs & derivatives)
• Humans
• Infant, Newborn
• Infant, Premature
• Male
• Platelet Count
• Recombinant Proteins (therapeutic use)
• Thrombocytopenia (chemically induced, diagnosis, drug therapy)