Deletion 6q as a recurrent chromosomal aberration in T-cell large granular lymphocyte leukemia.

Abstract

T-cell large granular lymphocyte (T-LGL) leukemia is an uncommon disease, with limited information on karyotypic aberrations. No consistent chromosomal changes have thus far been described. We report two cases of T-LGL leukemia who presented with severe anemia. The LGL were CD3+, CD4-, CD8+, CD56-, and CD161-, with variable expression of CD94, CD158a, and CD158b, and had clonal T-cell receptor gene rearrangement. A deletion of the long arm of chromosome 6 was the sole aberration in both cases. This is the first report of a recurrent chromosomal aberration in T-LGL leukemia.

• Authors: C Man, W Y Au, A Pang, Y L Kwong
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 139 Issue 1 Pg. 71-4 (Nov 2002) ISSN: 0165-4608 [Print] United States
• PMID: 12547164 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD

Topics

• Antigens, CD (genetics)
• Burkitt Lymphoma (genetics)
• Chromosome Aberrations
• Chromosome Mapping
• Chromosomes, Human, Pair 6
• Humans
• Karyotyping