Protective effects of xanthones against myocardial ischemia-reperfusion injury in rats.

Abstract

AIM:

To investigate the protective effect of xanthones against myocardial ischemia-reperfusion injury in rats.

METHODS:

Ischemia-reperfusion injury was induced by 20 min of global ischemia and 40 min of reperfusion in isolated rat hearts or 60-min coronary artery occlusion and 180-min reperfusion in vivo, respectively. Heart rate, coronary flow, left ventricular pressure (LVP), and its first derivative (+/- dp/dtmax) were recorded, and the activity of creatine kinase in coronary effluent and malondialdehyde contents in myocardial tissues were measured in vitro. The activity of serum creatine kinase and myocardium infarct size were measured in vivo.

RESULTS:

Xanthones (90 or 300 microg/L) caused a significant improvement of cardiac function (LVP and +/- dp/dtmax) and a decrease in the release of creatine kinase in coronary effluent as well as the level of malondialdehyde in myocardial tissues. Xanthones (0.5 or 1.0 mg/kg) also markedly decreased infarct size and the release of creatine kinase in vivo.

CONCLUSION:

Xanthones protect the myocardium against the damages induced by ischemia-reperfusion in rats, and the effect of xanthones may be related to the inhibition of lipid peroxidation.

• Authors: De-Jian Jiang, Gui-Shan Tan, Feng Ye, Yan-Hua Du, Kang-Ping Xu, Yuan-Jian Li
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 24 Issue 2 Pg. 175-80 (Feb 2003) ISSN: 1671-4083 [Print] United States
• PMID: 12546727 (Publication Type: Journal Article)

Chemical References

• Cardiotonic Agents
• Xanthones
• Malondialdehyde
• Creatine Kinase

Topics

• Animals
• Cardiotonic Agents (pharmacology)
• Coronary Circulation (drug effects)
• Creatine Kinase (blood)
• Heart (drug effects, physiopathology)
• Heart Rate (drug effects)
• In Vitro Techniques
• Lipid Peroxidation (drug effects)
• Male
• Malondialdehyde (metabolism)
• Myocardial Ischemia
• Myocardial Reperfusion Injury (enzymology, metabolism, physiopathology)
• Myocardium (metabolism, pathology)
• Plants, Medicinal (chemistry)
• Rats
• Rats, Wistar
• Swertia (chemistry)
• Ventricular Pressure (drug effects)
• Xanthones (isolation & purification, pharmacology)