Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine.

Abstract

BACKGROUND:

Hemorrhage is a leading cause of death from trauma. An advanced hemostatic dressing could augment available hemostatic methods. We studied the effects of a new chitosan dressing on blood loss, survival, and fluid use after severe hepatic injury in swine.

METHODS:

Swine received chitosan dressings or gauze sponges. Standardized, severe liver injuries were induced. After 30 seconds, dressings were applied and resuscitation initiated. Blood loss, hemostasis, resuscitation volume, and 60-minute survival were quantified.

RESULTS:

Posttreatment blood loss was reduced ( p< 0.01) in the chitosan group (264 mL; 95% confidence interval [CI], 82-852 mL) compared with the gauze group (2,879 mL; 95% CI, 788-10,513 mL). Fluid use was reduced ( p= 0.03) in the chitosan group (1,793 mL; 95% CI, 749-4,291) compared with the gauze group (6,614 mL; 95% CI, 2,519-17,363 mL). Survival was seven of eight and two of even in the chitosan and gauze groups ( p= 0.04), respectively. Hemostasis was improved in the chitosan group ( p= 0.03).

CONCLUSION:

A chitosan dressing reduced hemorrhage and improved survival after severe liver injury in swine. Further studies are warranted.

• Authors: Anthony E Pusateri, Simon J McCarthy, Kenton W Gregory, Richard A Harris, Luis Cardenas, Albert T McManus, Cleon W Goodwin Jr
• Journal: The Journal of trauma (J Trauma) Vol. 54 Issue 1 Pg. 177-82 (Jan 2003) ISSN: 0022-5282 [Print] United States
• PMID: 12544915 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Hemostatics
• Chitin
• Chitosan

Topics

• Animals
• Bandages (standards)
• Blood Volume
• Chitin (analogs & derivatives, therapeutic use)
• Chitosan
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Female
• Fluid Therapy (methods)
• Hemorrhage (diagnosis, etiology, mortality, therapy)
• Hemostatic Techniques (standards)
• Hemostatics (therapeutic use)
• Liver (injuries)
• Male
• Random Allocation
• Resuscitation (methods)
• Survival Analysis
• Swine
• Time Factors