Abstract | HYPOTHESIS: BACKGROUND: METHODS:
Etanercept was administered either systemically (2.5 mg) 30 minutes before intracochlear challenge with keyhole limpet hemocyanin, with a second intraperitoneal dose (2.5 mg) 3 days later or locally by long-term infusion into the scala tympani with an osmotic pump (5.0 microg/h for 7 days). Auditory evoked brainstem response thresholds were measured before and after treatment to determine hearing loss. Cochleas were evaluated for the amount of inflammation. RESULTS:
Hearing loss in the untreated systemic group averaged 71 +/- 21 dB versus 37 +/- 32 dB in the etanercept-treated animals (t test, P < 0.001). There was also less inflammation in the cochleas from etanercept-treated animals (t test, P < 0.01). Hearing loss with local administration of etanercept was 59 +/- 31 dB in the nontreated ears and 18 +/- 8 dB in the treated ears (t test, P < 0.02). Inflammation was also less (t test, P < 0.01). Etanercept was not ototoxic. CONCLUSION: Prompt intervention with the anti-inflammatory drug etanercept significantly reduces inflammation sufficient for substantive hearing preservation.
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Authors | Xiaobo Wang, Tim Truong, Peter B Billings, Jeffrey P Harris, Elizabeth M Keithley |
Journal | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
(Otol Neurotol)
Vol. 24
Issue 1
Pg. 52-7
(Jan 2003)
ISSN: 1531-7129 [Print] United States |
PMID | 12544029
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Immunoglobulin G
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
- Hemocyanins
- keyhole-limpet hemocyanin
- Etanercept
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Auditory Threshold
(drug effects)
- Autoimmune Diseases
(immunology, pathology)
- Etanercept
- Female
- Guinea Pigs
- Hearing Loss, Sensorineural
(immunology, pathology)
- Hemocyanins
(immunology)
- Immunity, Cellular
(drug effects, immunology)
- Immunoglobulin G
(pharmacology)
- Infusion Pumps
- Labyrinthitis
(immunology, pathology)
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors, physiology)
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