[Detection of HPV-DNA and humoral immunity in juvenile laryngeal papilloma].

Abstract

OBJECTIVE:

To study HPV infection route and pathogenesis of juvenile laryngeal papilloma(JLP).

METHOD:

HPV-DNA of JLP was detected with PCR and PCR product dot blot hybridization. Serum Ig and complement 3(C3) was detected with nephelometry.

RESULT:

HPV total positive rate in JLP was 95%(19/20). HPV6 was 55%(11/20). HPV11 was 30%(6/20), and HPV6 + 11 was 10%(2/20). Serum IgG, IgA, IgM and C3 of JLP were normal, no significant difference between JLP and the control group(P > 0.05).

CONCLUSION:

HPV6 infection of JLP was in the majority. And the type was consistent with the type of female genital organ pointed condyloma. Humoral immunity was negligible in HPV infection. Pathologic picture of different HPV type infection was identical.

• Authors: B B Chen, Q Y Bao, Z M Wang, J X Jin, S Y Huang, Y Y Chen
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 14 Issue 6 Pg. 262-4 (Jun 2000) China
• PMID: 12541534 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Complement C3
• DNA, Viral
• Immunoglobulins

Topics

• Child
• Child, Preschool
• Complement C3 (analysis)
• DNA, Viral (analysis)
• Female
• Humans
• Immunoglobulins (blood)
• Infant
• Laryngeal Neoplasms (immunology, virology)
• Male
• Papilloma (immunology, virology)
• Papillomaviridae (genetics, isolation & purification)
• Papillomavirus Infections
• Tumor Virus Infections