Vascular endothelial growth factor (VEGF-A) plasma levels in non-small cell lung cancer: relationship with coagulation and platelet activation markers.
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| Abstract |
Platelet activation, commonly found in lung cancer patients, may cause the release of angiogenic factors, such as vascular endothelial growth factor (VEGF-A). The present study was designed to investigate whether plasma VEGF-A levels were associated to different stages of non-small cell lung cancer (NSCLC). Moreover, sP-selectin, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complex (TATc) and D-dimer levels were measured to test the hypothesis of an involvement of platelet and coagulation activation in tumor angiogenesis. VEGF-A, sP-selectin, F1+2, TATc and D-dimer levels were elevated in 65 patients with NSCLC, particularly in metastatic patients. sP-selectin (p <0.003) and F1+2 (p <0.005) levels were independently associated to VEGF-A. In addition, patients with positive levels of both sP-selectin and F1+2 had the highest levels of VEGF-A. In conclusion, our findings support the hypothesis that thrombin generation might induce platelet activation and VEGF-A release in NSCLC.
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| Authors | Mario Roselli, Tommaso C Mineo, Stefania Basili, Sabrina Mariotti, Francesca Martini, Annamaria Bellotti, Vincenzo Ambrogi, Antonella Spila, Roberta D'Alessandro, Pier Paolo Gazzaniga, Fiorella Guadagni, Patrizia Ferroni |
| Journal | Thrombosis and haemostasis (Thromb Haemost) Vol. 89 Issue 1 Pg. 177-84 (Jan 2003) ISSN: 0340-6245 [Print] Germany |
| PMID | 12540968 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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