Abstract | OBJECTIVES: The incidence of cancer among employees of a Norwegian asbestos-cement factory was studied in relation to duration of exposure and time since first exposure. The factory was active in 1942-1968. Most of the asbestos in use was chrysotile, but for technical reasons 8% amphiboles was added. METHODS: For the identification of cancer cases, a cohort of 541 male workers was linked to the Cancer Registry of Norway. The analysis was based on the comparison between the observed and expected number of cancer cases. Standardized incidence ratios (SIR) and 95% confidence intervals (95% CI) were estimated. Period of first employment, duration of employment, and time since first employment were used as indicators of exposure. Poisson regression analysis was used for the internal comparisons. RESULTS: The standardized incidence ratio was 52.5 (95% CI 31.1-83.0) for pleural mesothelioma, on the basis of 18 cases. The highest standardized incidence ratio was found for workers first employed in the earliest production period (SIR 99.0, 95% CI 51.3-173). No peritoneal mesothelioma was found. The standardized incidence ratio for lung cancer was 3.1 (95% CI 2.14.3), but no dose-response effect was observed. The ratio of mesothelioma to lung cancer cases was 1:2. CONCLUSIONS:
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Authors | Bente Ulvestad, Kristina Kjaerheim, Jan Ivar Martinsen, Grete Damberg, Axel Wannag, Gunnar Mowe, Aage Andersen |
Journal | Scandinavian journal of work, environment & health
(Scand J Work Environ Health)
Vol. 28
Issue 6
Pg. 411-7
(Dec 2002)
ISSN: 0355-3140 [Print] Finland |
PMID | 12539801
(Publication Type: Journal Article)
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Chemical References |
- Asbestos, Amphibole
- Asbestos, Serpentine
- Asbestos, Crocidolite
- Asbestos
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Topics |
- Aged
- Asbestos
(adverse effects, classification)
- Asbestos, Amphibole
(adverse effects)
- Asbestos, Crocidolite
(adverse effects)
- Asbestos, Serpentine
(adverse effects)
- Cohort Studies
- Follow-Up Studies
- Humans
- Incidence
- Industry
- Lung Neoplasms
(epidemiology, etiology)
- Male
- Mesothelioma
(epidemiology, etiology)
- Middle Aged
- Neoplasms
(classification, epidemiology, etiology)
- Norway
(epidemiology)
- Occupational Exposure
(adverse effects)
- Poisson Distribution
- Registries
- Risk Factors
- Time
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