Abstract | BACKGROUND: Prostatic adenocarcinoma is the most common malignancy among men in the western world but the diagnostic and prognostic criteria for it are still not clearly defined. Additional means for its diagnosis and prognosis are clearly needed. Previously it has been shown that cystatin A is expressed in the basal cells of normal prostate and the expression disappears in prostatic carcinoma. METHODS: RESULTS:
Cystatin A was expressed in the basal cells in all cases of BPH, low-grade PIN, and high-grade PIN whereas carcinomas showed no staining of cystatin A. The 34 beta E12 cytokeratin expression was similar to basal cystatin A staining and was not seen in carcinoma foci. Cystatin B showed both nuclear and cytoplasmic expression in the columnar epithelial cells. The decrease in median cytoplasmic staining of cystatin B in carcinomas compared to other lesions was significant, but there was a significant increase in expression with dedifferentiation of carcinoma. Also cyclin A and Ki-67 staining were significantly different in non-carcinomatous foci compared to carcinoma foci and had a remarkably similar negative correlations with basal cystatin A and 34 beta E12 staining. CONCLUSIONS:
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Authors | Tuomas Mirtti, Kalle Alanen, Markku Kallajoki, Ari Rinne, Karl-Ove Söderström |
Journal | The Prostate
(Prostate)
Vol. 54
Issue 4
Pg. 290-8
(Mar 01 2003)
ISSN: 0270-4137 [Print] United States |
PMID | 12539227
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2003 Wiley-Liss, Inc. |
Chemical References |
- Biomarkers, Tumor
- CSTB protein, human
- Cyclin B
- Cystatins
- Ki-67 Antigen
- Keratins
- Cystatin B
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Topics |
- Adenocarcinoma
(chemistry, pathology)
- Aged
- Biomarkers, Tumor
(analysis)
- Cell Division
- Cyclin B
(analysis)
- Cystatin B
- Cystatins
(analysis)
- Humans
- Keratins
(analysis, chemistry)
- Ki-67 Antigen
(analysis)
- Male
- Middle Aged
- Molecular Weight
- Neoplasm Recurrence, Local
- Predictive Value of Tests
- Prognosis
- Prostatic Hyperplasia
(metabolism, pathology)
- Prostatic Neoplasms
(chemistry, pathology)
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