Abstract |
Phenazone metabolism was studied in 14 patients with liver disease and six normal volunteers. The plasma and renal clearance of phenazone and the 4-hydrozyphenazone excretion in urine was significantly decreased in the patients with liver disease. The urinary excretion of 4-hydroxyphenazone was significantly correlated to the plasma clearance of phenazone (r= + 0.95, P less than 0.001), to quantitative liver function as measured by the galactose elimination capacity (r= + 0.95, P less than 0.001), and to the prothrombin values (r= + 0.82, P less than 0.001). The determination of the 4-hydroxyphenazone excretion in urine may be used as an easy and non-invasive test of quantitative liver function.
|
Authors | P B Andreasen, G Greisen |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 6
Issue 1
Pg. 21-6
(Jan 30 1976)
ISSN: 0014-2972 [Print] England |
PMID | 1253807
(Publication Type: Journal Article)
|
Chemical References |
- Creatinine
- Antipyrine
- Galactose
|
Topics |
- Adult
- Aged
- Antipyrine
(metabolism)
- Creatinine
(metabolism)
- Galactose
(metabolism)
- Humans
- Injections, Intravenous
- Kinetics
- Liver Diseases
(diagnosis, metabolism)
- Liver Function Tests
(methods)
- Male
- Middle Aged
|