[Inhibitory effect of the combination of DHPAs and hyperbaric oxygen on Japanese B encephalitis virus infection in mice].

Abstract

OBJECTIVE:

To investigate the inhibitory effect of the combination of 2,3-dihydroxypropyl-adenine (DHPAs) and hyperbaric oxygen (HBO) on Japanese B encephalitis virus infection in mice.

METHODS:

Mice infected P3-55 and P3-53 virus were used in the experiments. Virus was inoculated intraperitoneally to Kumming strain mice (8.5-9.5 g). Mice were divided into groups and treated in the incubation period of the infection. The duration of treatment was 5 days, and the experiments were terminated at the end of 2 weeks after treatment. The living and the dead were then counted finally.

RESULTS:

The intergroup comparison showed marked difference between the control group and combination of DHPAs and hyperbaric oxygen group (P < 0.025 and P < 0.01), but there was no statistical difference between other groups and the control group (P > 0.05).

CONCLUSION:

The combined treatment of (S) DHPA and/or (RS)-DHPA and HBO has inhibitory effect on Japanese encephalitis virus infection in experimental mice.

• Authors: M H Lu, H E Xiong, D M Tan
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 26 Issue 2 Pg. 129-30 (Apr 28 2001) ISSN: 1000-5625 [Print] China
• PMID: 12536643 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• 9-(2,3-dihydroxypropyl)adenine
• Adenine

Topics

• Adenine (analogs & derivatives, pharmacology, therapeutic use)
• Animals
• Antiviral Agents (pharmacology, therapeutic use)
• Encephalitis Virus, Japanese (drug effects)
• Encephalitis, Japanese (therapy, virology)
• Hyperbaric Oxygenation
• Mice
• Random Allocation