[Effects of Stat3 phosphorylation and expression of c-fos and c-jun proteins on hepatocarcinogenesis].

Abstract

Expression of phosphorylated Stat3 (p-Stat3), c-fos and c-jun proteins was detected by immunohistochemical technique in 55 hepatocellular carcinomas (HCC) and their surrounding liver tissues. The results showed that the positive rates and signal intensity of p-Stat3, c-fos and c-jun protein in HCCs were significantly higher than those in pericarcinomatous tissues. The expressive intensity of c-fos and c-jun proteins was positively related to p-Stat3 expression in HCCs, whereas the positive correlation of expressive intensity was only observed between c-jun protein and p-Stat3 in pericarcinomatous tissues. The data suggest that the phosphorylation of Stat3 may be an early event in hepatocarcinogenesis; the overexpression of p-Stat3 protein, which activates c-fos and c-jun genes, may contribute to malignant transformation of hepatocytes; hepatocytes which expressed p-Stat3, c-fos or c-jun proteins may be potentially malignant pre-cancer cells in pericarcinomatous liver tissues.

• Authors: D Y Feng, H Zheng, H Y Jiang
• Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 26 Issue 1 Pg. 17-9 (Feb 28 2001) ISSN: 1000-5625 [Print] China
• PMID: 12536605 (Publication Type: English Abstract, Journal Article)

Chemical References

• Acute-Phase Proteins
• DNA-Binding Proteins
• Proto-Oncogene Proteins c-fos
• Proto-Oncogene Proteins c-jun
• STAT3 Transcription Factor
• STAT3 protein, human
• Trans-Activators

Topics

• Acute-Phase Proteins (metabolism)
• Adult
• Aged
• Carcinoma, Hepatocellular (chemistry)
• DNA-Binding Proteins (metabolism)
• Female
• Humans
• Liver Neoplasms (chemistry)
• Male
• Middle Aged
• Phosphorylation
• Proto-Oncogene Proteins c-fos (biosynthesis)
• Proto-Oncogene Proteins c-jun (biosynthesis)
• STAT3 Transcription Factor
• Signal Transduction
• Trans-Activators (metabolism)