[The measurement of 153Sm-EDTMP bone uptake rate and its relationship with therapeutic effect].

Abstract

OBJECTIVE:

To evaluate the measurement of 153Sm-EDTMP Bone uptake rate with whole-body scintigraphy and analyze the relationship between bone uptake rate and therapeutic effect.

METHODS:

66 patients with bony metastases were examined with whole-body scintigraphy 10 minutes and 6 hours after the administration of 153Sm-EDTMP, and then bone uptake rate was calculated.

RESULTS:

The bone uptake rate in 66 patients ranged from 31.9% to 86.6%, (mean 56.0%). The patients with higher bone uptake rate had better overall therapeutic effect. According to the bone uptake rate calculated by whole-body scintigraphy, the therapy activity administered within the limit of bone marrow absorbed dose of 1400 mGy in these patients was 1.40-2.27GBq (mean 1.90 GBq).

CONCLUSION:

The present authors have developed a whole-body scintigraphic technique which is simple and reliable in calculating prospectively a safe and effective dose of 153Sm-EDTMP for palliating the patient's painful bone metastases without myelotoxicity.

• Authors: L Li, Z Liang, H Deng, Y Li, X Zhang, X Yang
• Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao (Hua Xi Yi Ke Da Xue Xue Bao) Vol. 32 Issue 3 Pg. 446-8 (Sep 2001) ISSN: 0257-7712 [Print] China
• PMID: 12536590 (Publication Type: Journal Article)

Chemical References

• Organometallic Compounds
• Organophosphorus Compounds
• samarium Sm-153 lexidronam

Topics

• Adult
• Aged
• Bone Neoplasms (diagnostic imaging, secondary)
• Bone and Bones (diagnostic imaging, metabolism)
• Breast Neoplasms (diagnostic imaging, pathology)
• Female
• Humans
• Lung Neoplasms (diagnostic imaging, pathology)
• Male
• Middle Aged
• Organometallic Compounds (pharmacokinetics, therapeutic use)
• Organophosphorus Compounds (pharmacokinetics, therapeutic use)
• Radionuclide Imaging