Abstract | BACKGROUND: METHODS: The effects of methylprednisolone therapy on recovery of somatosensory evoked potentials and on spinal cord blood flow were examined in a canine model of dynamic spinal cord compression. Methylprednisolone (30 mg/kg intravenous loading dose followed by 5.4 mg/kg/hr intravenous infusion) or saline solution was administered to thirty-six beagles (eighteen in each group) five minutes after cessation of dynamic spinal cord compression and loss of all somatosensory evoked potentials. After ninety minutes of sustained compression, the spinal cords were decompressed. Somatosensory evoked potentials and spinal cord blood flow were evaluated throughout the period of sustained compression and for three hours after decompression. RESULTS: CONCLUSIONS: The methylprednisolone administered in this study did not provide a large or significant lasting benefit with regard to neurological preservation or restoration. Methylprednisolone may reduce regional spinal cord blood flow through mechanisms affecting normal autoregulatory blood-flow function.
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Authors | Gregory D Carlson, Carey D Gorden, Shigenobu Nakazawa, Eiji Wada, Jeremy S Smith, Joseph C LaManna |
Journal | The Journal of bone and joint surgery. American volume
(J Bone Joint Surg Am)
Vol. 85
Issue 1
Pg. 95-101
(Jan 2003)
ISSN: 0021-9355 [Print] United States |
PMID | 12533578
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Neuroprotective Agents
- Methylprednisolone
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Topics |
- Animals
- Biomechanical Phenomena
- Disease Models, Animal
- Dogs
- Evoked Potentials, Somatosensory
(drug effects, physiology)
- Methylprednisolone
(pharmacology, therapeutic use)
- Neuroprotective Agents
(pharmacology, therapeutic use)
- Recovery of Function
(drug effects, physiology)
- Regional Blood Flow
(drug effects, physiology)
- Spinal Cord
(drug effects, physiopathology)
- Spinal Cord Compression
(complications, drug therapy, physiopathology)
- Spinal Cord Injuries
(drug therapy, etiology, physiopathology)
- Time Factors
- Trauma Severity Indices
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