The age-dependent efficacy of polyadenylic-polyuridylic acid therapy upon the development of spontaneous leukemia in AKR mice.

Abstract

The synthetic double-stranded polynucleotide, polyadenylic-polyuridylic acid, has been shown to increase the long-term survival of AKR mice. In order to determine whether this effect was age dependent, polyadenylic-polyuridylic acid was administered to AKR mice starting at 2, 4, 6, or 8 months of age. The best therapeutic effect was achieved when polyadenylic-polyuridylic acid treatments were begun at 2 months of age, and there was no beneficial effect when begun at 8 months of age.

• Authors: W P Drake, W J Pendergrast Jr, R E Kramer, M R Mardiney Jr
• Journal: Cancer research (Cancer Res) Vol. 36 Issue 3 Pg. 1172-5 (Mar 1976) ISSN: 0008-5472 [Print] United States
• PMID: 1253174 (Publication Type: Journal Article)

Chemical References

• Poly A-U

Topics

• Age Factors
• Animals
• Female
• Leukemia, Lymphoid (drug therapy)
• Mice
• Poly A-U (therapeutic use)