[Meloxicam (Mobic): a review of its pharmacological and clinical profile].

Abstract	Meloxicam (Mobic) is a new nonsteroidal anti-inflammatory drug (NSAID) derived from enolic acid, exhibiting selectivity for cyclooxygenase (COX)-2 over COX-1. Meloxicam has shown potent anti-inflammatory and analgesic activity together with low gastrointestinal toxicity in animal models. It is a potent inhibitor not only of acute exudation in adjuvant arthritis in the rat, but also of bone and cartilage destruction. The therapeutic range of meloxicam in the rat, with regard to inhibition of adjuvant arthritis, was several times greater than that of other NSAIDs. Meloxicam in therapeutic doses was found to have no effect on bleeding time or platelet aggregation in healthy volunteers. In clinical studies, meloxicam has shown reliable efficacy against rheumatoid arthritis, osteoarthritis, lumbago (low back pain), scapulohumeral periarthritis, and neck-shoulder-arm syndrome with low gastrointestinal toxicity.
Authors	Keiko Ogino, Kazushige Saito, Takeshi Osugi, Hisashi Satoh
Journal	Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 120 Issue 6 Pg. 391-7 (Dec 2002) ISSN: 0015-5691 [Print] Japan
PMID	12528470 (Publication Type: Journal Article, Review)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Enzyme Inhibitors Isoenzymes Membrane Proteins Thiazines Thiazoles Cyclooxygenase 2 PTGS2 protein, human Prostaglandin-Endoperoxide Synthases Meloxicam
Topics	Animals Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects, pharmacology) Arthritis, Experimental (drug therapy) Arthritis, Rheumatoid (drug therapy) Clinical Trials as Topic Cyclooxygenase 2 Enzyme Inhibitors (administration & dosage, adverse effects, pharmacology) Gastric Mucosa (drug effects) Gastrointestinal Hemorrhage (chemically induced) Humans Inflammation (drug therapy) Isoenzymes (antagonists & inhibitors) Meloxicam Membrane Proteins Pain (drug therapy) Platelet Aggregation (drug effects) Prostaglandin-Endoperoxide Synthases Rats Thiazines (administration & dosage, adverse effects, pharmacology) Thiazoles (administration & dosage, adverse effects, pharmacology)

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