Abstract |
We used single photon emission computed tomography (SPECT) to study striatal [(123)I] beta-CIT binding and polysomnography to study periodic leg movements during sleep (PLMS) in eleven patients with idiopathic Parkinson's disease (PD). The reduced striatal [(123)I] beta-CIT binding was significantly correlated with the number of PLMS. We propose that striatal dopaminergic nerve cell loss is involved in the increased number of PLMS in PD patients.
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Authors | Svenja Happe, Walter Pirker, Gerhard Klösch, Cornelia Sauter, Josef Zeitlhofer |
Journal | Journal of neurology
(J Neurol)
Vol. 250
Issue 1
Pg. 83-6
(Jan 2003)
ISSN: 0340-5354 [Print] Germany |
PMID | 12527997
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dopamine Plasma Membrane Transport Proteins
- Membrane Glycoproteins
- Membrane Transport Proteins
- Nerve Tissue Proteins
- Radiopharmaceuticals
- 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
- Cocaine
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Topics |
- Aged
- Cocaine
(analogs & derivatives)
- Corpus Striatum
(diagnostic imaging, metabolism, pathology)
- Dopamine Plasma Membrane Transport Proteins
- Female
- Humans
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
(metabolism)
- Middle Aged
- Nerve Tissue Proteins
- Nocturnal Myoclonus Syndrome
(metabolism, physiopathology)
- Parkinson Disease
(diagnostic imaging, metabolism, physiopathology)
- Polysomnography
- Radiopharmaceuticals
- Tomography, Emission-Computed, Single-Photon
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