HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster.

Abstract
Several lines of evidence indicate that selenoproteins mainly act as cellular antioxidants. Here, we test this idea comparing the sensitivity to oxidative stress (paraquat and hydrogen peroxide) between wild type and heterozygous flies for the selenophosphate synthetase selD(ptuf) mutation. Whereas under normal laboratory conditions no difference in life span is observed, a significant decrease is seen in heterozygous flies treated with oxidant agents. In contrast, overexpression of the selD gene in motoneurons did not extend longevity. Our results strongly suggest that selD haploinsufficiency makes heterozygous flies more sensitive to oxidative stress and add further evidence to the role of selenoproteins as cellular antioxidants.
AuthorsMarta Morey, Florenci Serras, Montserrat Corominas
JournalFEBS letters (FEBS Lett) Vol. 534 Issue 1-3 Pg. 111-4 (Jan 16 2003) ISSN: 0014-5793 [Print] England
PMID12527370 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drosophila Proteins
  • Hydrogen Peroxide
  • Phosphotransferases
  • selenophosphate synthetase
  • sps1 protein, Drosophila
  • Paraquat
Topics
  • Animals
  • Drosophila Proteins (genetics)
  • Drosophila melanogaster (drug effects, physiology)
  • Gene Dosage
  • Gene Expression Regulation
  • Heterozygote
  • Hydrogen Peroxide (toxicity)
  • Longevity (genetics)
  • Male
  • Motor Neurons (physiology)
  • Oxidative Stress
  • Paraquat (toxicity)
  • Phosphotransferases (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: