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Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis.

Abstract
Cetyl myristoleate (CM) was reported by Diehl and May [J Pharm Sci 83 (1994) 296] to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure CM and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple intraperitoneal injections of CM in 450 and 900 mg kg(-1) doses resulted in a significantly lower incidence of disease and caused a modest but significant diminution in clinical signs in those mice that developed arthritis. CM administered in daily oral doses of 20 mg kg(-1) also reduced the incidence of arthritis and caused a small reduction in the clinical signs in mice that developed arthritis. Although the protective effect of CM in collagen-induced arthritis observed in the present study was less dramatic than that reported earlier, our results confirm the anti-arthritic properties of pure CM.
AuthorsKenneth W Hunter Jr, Ruth A Gault, Jeffrey S Stehouwer, Suk-Wah Tam-Chang
JournalPharmacological research (Pharmacol Res) Vol. 47 Issue 1 Pg. 43-7 (Jan 2003) ISSN: 1043-6618 [Print] Netherlands
PMID12526860 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Waxes
  • cetyl myristoleate
Topics
  • Animals
  • Arthritis, Experimental (drug therapy, pathology)
  • Disease Models, Animal
  • Drug Evaluation, Preclinical (methods)
  • Female
  • Mice
  • Mice, Inbred DBA
  • Waxes (chemical synthesis, therapeutic use)

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