Abstract |
Cetyl myristoleate (CM) was reported by Diehl and May [J Pharm Sci 83 (1994) 296] to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure CM and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple intraperitoneal injections of CM in 450 and 900 mg kg(-1) doses resulted in a significantly lower incidence of disease and caused a modest but significant diminution in clinical signs in those mice that developed arthritis. CM administered in daily oral doses of 20 mg kg(-1) also reduced the incidence of arthritis and caused a small reduction in the clinical signs in mice that developed arthritis. Although the protective effect of CM in collagen-induced arthritis observed in the present study was less dramatic than that reported earlier, our results confirm the anti-arthritic properties of pure CM.
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Authors | Kenneth W Hunter Jr, Ruth A Gault, Jeffrey S Stehouwer, Suk-Wah Tam-Chang |
Journal | Pharmacological research
(Pharmacol Res)
Vol. 47
Issue 1
Pg. 43-7
(Jan 2003)
ISSN: 1043-6618 [Print] Netherlands |
PMID | 12526860
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Arthritis, Experimental
(drug therapy, pathology)
- Disease Models, Animal
- Drug Evaluation, Preclinical
(methods)
- Female
- Mice
- Mice, Inbred DBA
- Waxes
(chemical synthesis, therapeutic use)
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